The quality control machinery regulates the cellular proteome to ensure proper protein homeostasis (proteostasis).In Caenorhabditis elegans, quality control networks Tiles are downregulated cell-nonautonomously by the gonadal longevity pathway or metabolic signaling at the onset of reproduction.However, how signals are mediated between the gonad an
IntroductionMultisectoral action is a central component of the global response to the rising prevalence of non-communicable diseases (NCDs).In this paper we aimed to unpack the definition of multisectoral action and provide an overview of the historical context, challenges, and recommendations alongside three country case studies: salt reduction in
Elastic metagratings enabling independent and complete control of both reflection and transmission of bulk longitudinal and transverse waves are highly desired in application scenarios such as non-destructive assessment and structural health monitoring.In this work, we propose a kind of simply structured metagrating composed only Heart Rate Grip Pa
Since internal marketing (IM) treats employees as customers, the focus has naturally been on internal measures.However, consumer-oriented advertising provides an opportunity for employees to recognize the social impact of their work and change their mindset.Such activities can be seen in business, but knowledge based on academic research is scarce.
D1 and D2 receptor expressing striatal medium spiny neurons (MSNs) are ascribed to striatonigral ("direct") and striatopallidal ("indirect") pathways, respectively, that are believed to function antagonistically in motor control.Glutamatergic synaptic transmission onto the two types is differentially affected by Dopamine (DA), however, less is know